Gregory J. Hannon’s publications:

Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export.

Kneuss E, Munafò M, Eastwood EL, Deumer US, Preall JB, Hannon GJ, Czech B; Genes Dev. 2019 09 01;33(17-18):1208-1220

lncRNA requirements for mouse acute myeloid leukemia and normal differentiation.

Delás MJ, Sabin LR, Dolzhenko E, Knott SR, Munera Maravilla E, Jackson BT, Wild SA, Kovacevic T, Stork EM, Zhou M, Erard N, Lee E, Kelley DR, Roth M, Barbosa ISA, Zuber J, Rinn JL, Smith AD, Hannon GJ. Elife. 2017 Sep 06;6:

lncRNAs in development and disease: from functions to mechanisms.

Delás MJ, Hannon GJ. Open Biol. 2017 Jul;7(7):

A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout.

Erard N, Knott SRV, Hannon GJ. Mol Cell. 2017 Jul 20;67(2):348-354.e4

A Model for Epigenetic Inhibition via Transvection in the Mouse.

Rodriguez JD, Myrick DA, Falciatori I, Christopher MA, Lee TW, Hannon GJ, Katz DJ. Genetics. 2017 Sep;207(1):129-138

BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells.

Frey WD, Chaudhry A, Slepicka PF, Ouellette AM, Kirberger SE, Pomerantz WCK, Hannon GJ, Dos Santos CO. Stem Cell Reports. 2017 Jul 11;9(1):23-31

TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells.

Pal D, Pertot A, Shirole NH, Yao Z, Anaparthy N, Garvin T, Cox H, Chang K, Rollins F, Kendall J, Edwards L, Singh VA, Stone GC, Schatz MC, Hicks J, Hannon GJ, Sordella R. Elife. 2017 Jan 16;6:

Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.

McFadden DG, Politi K, Bhutkar A, Chen FK, Song X, Pirun M, Santiago PM, Kim-Kiselak C, Platt JT, Lee E, Hodges E, Rosebrock AP, Bronson RT, Socci ND, Hannon GJ, Jacks T, Varmus H. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6409-E6417

Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway.

Fagegaltier D, Falciatori I, Czech B, Castel S, Perrimon N, Simcox A, Hannon GJ. Genes Dev. 2016 Jul 15;30(14):1623-35

A Happy 3′ Ending to the piRNA Maturation Story.

Czech B, Hannon GJ. Cell. 2016 Feb 25;164(5):838-40

One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing.

Czech B, Hannon GJ. Trends Biochem Sci. 2016 Apr;41(4):324-37

Inducing RNAi in Caenorhabditis elegans by Injection of dsRNA.

Hammell CM, Hannon GJ. Cold Spring Harb Protoc. 2016 Jan 04;2016(1):pdb.prot086306

Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation.

Sanchez CG, Teixeira FK, Czech B, Preall JB, Zamparini AL, Seifert JR, Malone CD, Hannon GJ, Lehmann R. Cell Stem Cell. 2016 Feb 04;18(2):276-90

Panoramix enforces piRNA-dependent cotranscriptional silencing.

Yu Y, Gu J, Jin Y, Luo Y, Preall JB, Ma J, Czech B, Hannon GJ. Science. 2015 Oct 16;350(6258):339-42

Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization.

Dequéant ML, Fagegaltier D, Hu Y, Spirohn K, Simcox A, Hannon GJ, Perrimon N. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):12974-9

Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano.

Wasik K, Gurtowski J, Zhou X, Ramos OM, Delás MJ, Battistoni G, El Demerdash O, Falciatori I, Vizoso DB, Smith AD, Ladurner P, Schärer L, McCombie WR, Hannon GJ, Schatz M. Proc Natl Acad Sci U S A. 2015 Oct 06;112(40):12462-7

Dual functions of Macpiwi1 in transposon silencing and stem cell maintenance in the flatworm Macrostomum lignano.

Zhou X, Battistoni G, El Demerdash O, Gurtowski J, Wunderer J, Falciatori I, Ladurner P, Schatz MC, Hannon GJ, Wasik KA. RNA. 2015 Nov;21(11):1885-97

The Transgenic RNAi Project at Harvard Medical School: Resources and Validation.

Perkins LA, Holderbaum L, Tao R, Hu Y, Sopko R, McCall K, Yang-Zhou D, Flockhart I, Binari R, Shim HS, Miller A, Housden A, Foos M, Randkelv S, Kelley C, Namgyal P, Villalta C, Liu LP, Jiang X, Huan-Huan Q, Wang X, Fujiyama A, Toyoda A, Ayers K, Blum A, Czech B, Neumuller R, Yan D, Cavallaro A, Hibbard K, Hall D, Cooley L, Hannon GJ, Lehmann R, Parks A, Mohr SE, Ueda R, Kondo S, Ni JQ, Perrimon N. Genetics. 2015 Nov;201(3):843-52

RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.

Wasik KA, Tam OH, Knott SR, Falciatori I, Hammell M, Vagin VV, Hannon GJ. Genes Dev. 2015 Jul 01;29(13):1403-15

piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis.

Goh WS, Falciatori I, Tam OH, Burgess R, Meikar O, Kotaja N, Hammell M, Hannon GJ. Genes Dev. 2015 May 15;29(10):1032-44

An epigenetic memory of pregnancy in the mouse mammary gland.

Dos Santos CO, Dolzhenko E, Hodges E, Smith AD, Hannon GJ. Cell Rep. 2015 May 19;11(7):1102-9

ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation.

Teixeira FK, Sanchez CG, Hurd TR, Seifert JR, Czech B, Preall JB, Hannon GJ, Lehmann R. Nat Cell Biol. 2015 May;17(5):689-96

A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis.

Wagenblast E, Soto M, Gutiérrez-Ángel S, Hartl CA, Gable AL, Maceli AR, Erard N, Williams AM, Kim SY, Dickopf S, Harrell JC, Smith AD, Perou CM, Wilkinson JE, Hannon GJ, Knott SR. Nature. 2015 Apr 16;520(7547):358-62

Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi’s genomic targets still not identified.

Marinov GK, Wang J, Handler D, Wold BJ, Weng Z, Hannon GJ, Aravin AA, Zamore PD, Brennecke J, Toth KF. Dev Cell. 2015

Essential Role for endogenous siRNAs during meiosis in mouse oocytes.

Stein P, Rozhkov NV, Li F, Cárdenas FL, Davydenko O, Vandivier LE, Gregory BD, Hannon GJ, Schultz RM. PLoS Genet. 2015

Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil.

Malaspinas AS, Lao O, Schroeder H, Rasmussen M, Raghavan M, Moltke I, Campos PF, Sagredo FS, Rasmussen S, Gonçalves VF, Albrechtsen A, Allentoft ME, Johnson PL, Li M, Reis S, Bernardo DV, DeGiorgio M, Duggan AT, Bastos M, Wang Y, Stenderup J, Moreno-Mayar JV, et al. Curr Biol. 2014

A computational algorithm to predict shRNA potency.

Knott SR, Maceli AR, Erard N, Chang K, Marran K, Zhou X, Gordon A, El Demerdash O, Wagenblast E, Kim S, Fellmann C, Hannon GJ. Mol Cell. 2014

MicroRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development.

Deng L, Shang L, Bai S, Chen J, He X, Martin-Trevino R, Chen S, Li XY, Meng X, Yu B, Wang X, Liu Y, McDermott SP, Ariazi AE, Ginestier C, Ibarra I, Ke J, Luther T, Clouthier SG, Xu L, Shan G, Song E, et al. Cancer Res. 2014

Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence.

Yang M, Haase AD, Huang FK, Coulis G, Rivera KD, Dickinson BC, Chang CJ, Pappin DJ, Neubert TA, Hannon GJ, Boivin B, Tonks NK. Mol Cell. 2014

Two waves of de novo methylation during mouse germ cell development.

Molaro A, Falciatori I, Hodges E, Aravin AA, Marran K, Rafii S, McCombie WR, Smith AD, Hannon GJ. Genes Dev. 2014

Starvation-induced transgenerational inheritance of small RNAs in C. elegans.

Rechavi O, Houri-Ze’evi L, Anava S, Goh WS, Kerk SY, Hannon GJ, Hobert O. Cell. 2014

Generation of transgenic Drosophila expressing shRNAs in the miR-1 backbone.

Chang K, Marran K, Valentine A, Hannon GJ. Cold Spring Harb Protoc. 2014

Inducing RNAi in Drosophila cells by soaking with dsRNA.

Zhou R, Mohr S, Hannon GJ, Perrimon N. Cold Spring Harb Protoc. 2014

A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis.

Goh WS, Seah JW, Harrison EJ, Chen C, Hammell CM, Hannon GJ. Genes Dev. 2014

An atlas of chromatoid body components.

Meikar O, Vagin VV, Chalmel F, Sõstar K, Lardenois A, Hammell M, Jin Y, Da Ros M, Wasik KA, Toppari J, Hannon GJ, Kotaja N. RNA. 2014

Creating transgenic shRNA mice by recombinase-mediated cassette exchange.

Premsrirut PK, Dow LE, Park Y, Hannon GJ, Lowe SW. Cold Spring Harb Protoc. 2013

A genomic-scale artificial microRNA library as a tool to investigate the functionally redundant gene space in Arabidopsis.

Hauser F, Chen W, Deinlein U, Chang K, Ossowski S, Fitz J, Hannon GJ, Schroeder JI. Plant Cell. 2013

Infection of mammalian cells with retroviral shRNAs.

Chang K, Marran K, Valentine A, Hannon GJ. Cold Spring Harb Protoc. 2013

Packaging shRNA retroviruses.

Chang K, Marran K, Valentine A, Hannon GJ. Cold Spring Harb Protoc. 2013

Creating an miR30-based shRNA vector.

Chang K, Marran K, Valentine A, Hannon GJ. Cold Spring Harb Protoc. 2013

De novo DNA demethylation and noncoding transcription define active intergenic regulatory elements.

Schlesinger F, Smith AD, Gingeras TR, Hannon GJ, Hodges E. Genome Res. 2013

Minotaur is critical for primary piRNA biogenesis.

Vagin VV, Yu Y, Jankowska A, Luo Y, Wasik KA, Malone CD, Harrison E, Rosebrock A, Wakimoto BT, Fagegaltier D, Muerdter F, Hannon GJ. RNA. 2013

The making of a slicer: activation of human Argonaute-1.

Faehnle CR, Elkayam E, Haase AD, Hannon GJ, Joshua-Tor L. Cell Rep. 2013

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.

Kaaij LT, van de Wetering M, Fang F, Decato B, Molaro A, van de Werken HJ, van Es JH, Schuijers J, de Wit E, de Laat W, Hannon GJ, Clevers HC, Smith AD, Ketting RF. Genome Biol. 2013

A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila.

Muerdter F, Guzzardo PM, Gillis J, Luo Y, Yu Y, Chen C, Fekete R, Hannon GJ. Mol Cell. 2013

Dnmt2-dependent methylomes lack defined DNA methylation patterns.

Raddatz G, Guzzardo PM, Olova N, Fantappié MR, Rampp M, Schaefer M, Reik W, Hannon GJ, Lyko F. Proc Natl Acad Sci U S A. 2013

Inducing RNAi in Drosophila cells by transfection with dsRNA.

Zhou R, Mohr S, Hannon GJ, Perrimon N. Cold Spring Harb Protoc. 2013

Variations in COL15A1 and COL18A1 influence age of onset of primary open angle glaucoma.

Wiggs JL, Howell GR, Linkroum K, Abdrabou W, Hodges E, Braine CE, Pasquale LR, Hannon GJ, Haines JL, John SW. Clin Genet. 2013

Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells.

dos Santos CO, Rebbeck C, Rozhkova E, Valentine A, Samuels A, Kadiri LR, Osten P, Harris EY, Uren PJ, Smith AD, Hannon GJ. Proc Natl Acad Sci U S A. 2013

Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9.

Lu X, Wontakal SN, Kavi H, Kim BJ, Guzzardo PM, Emelyanov AV, Xu N, Hannon GJ, Zavadil J, Fyodorov DV, Skoultchi AI. Science. 2013

Dogma derailed: the many influences of RNA on the genome.

Sabin LR, Delás MJ, Hannon GJ. Mol Cell. 2013

Dicer-2 processes diverse viral RNA species.

Sabin LR, Zheng Q, Thekkat P, Yang J, Hannon GJ, Gregory BD, Tudor M, Cherry S. PLoS One. 2013

Multiple roles for Piwi in silencing Drosophila transposons.

Rozhkov NV, Hammell M, Hannon GJ. Genes Dev. 2013

The piRNA pathway in flies: highlights and future directions.

Guzzardo PM, Muerdter F, Hannon GJ. Curr Opin Genet Dev. 2013

Inducing RNAi in C. elegans by feeding with dsRNA-expressing E. coli.

Hammell CM, Hannon GJ. Cold Spring Harb Protoc. 2012

The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis.

Ipsaro JJ, Haase AD, Knott SR, Joshua-Tor L, Hannon GJ. Nature. 2012

Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length.

Bender HS, Murchison EP, Pickett HA, Deakin JE, Strong MA, Conlan C, McMillan DA, Neumann AA, Greider CW, Hannon GJ, Reddel RR, Graves JA. PLoS One. 2012

Preparation of small RNA libraries for high-throughput sequencing.

Malone C, Brennecke J, Czech B, Aravin A, Hannon GJ. Cold Spring Harb Protoc. 2012

Site identification in high-throughput RNA-protein interaction data.

Uren PJ, Bahrami-Samani E, Burns SC, Qiao M, Karginov FV, Hodges E, Hannon GJ, Sanford JR, Penalva LO, Smith AD. Bioinformatics. 2012

RNAi in cultured mammalian cells using synthetic siRNAs.

Chang K, Marran K, Valentine A, Hannon GJ. Cold Spring Harb Protoc. 2012

shutdown is a component of the Drosophila piRNA biogenesis machinery.

Preall JB, Czech B, Guzzardo PM, Muerdter F, Hannon GJ. RNA. 2012

MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells.

Liu S, Patel SH, Ginestier C, Ibarra I, Martin-Trevino R, Bai S, McDermott SP, Shang L, Ke J, Ou SJ, Heath A, Zhang KJ, Korkaya H, Clouthier SG, Charafe-Jauffret E, Birnbaum D, Hannon GJ, Wicha MS. PLoS Genet. 2012

The structure of human argonaute-2 in complex with miR-20a.

Elkayam E, Kuhn CD, Tocilj A, Haase AD, Greene EM, Hannon GJ, Joshua-Tor L. Cell. 2012

Genomic landscape of human allele-specific DNA methylation.

Fang F, Hodges E, Molaro A, Dean M, Hannon GJ, Smith AD. Proc Natl Acad Sci U S A. 2012

Modulators of prostate cancer cell proliferation and viability identified by short-hairpin RNA library screening.

Dahlman KB, Parker JS, Shamu T, Hieronymus H, Chapinski C, Carver B, Chang K, Hannon GJ, Sawyers CL. PLoS One. 2012

An alternative mode of microRNA target recognition.

Chi SW, Hannon GJ, Darnell RB. Nat Struct Mol Biol. 2012

Enhanced susceptibility of Ago1/3 double-null mice to influenza A virus infection.

Van Stry M, Oguin TH 3rd, Cheloufi S, Vogel P, Watanabe M, Pillai MR, Dash P, Thomas PG, Hannon GJ, Bix M. J Virol. 2012

A pipeline for the generation of shRNA transgenic mice.

Dow LE, Premsrirut PK, Zuber J, Fellmann C, McJunkin K, Miething C, Park Y, Dickins RA, Hannon GJ, Lowe SW. Nat Protoc. 2012

Cell-type-based analysis of microRNA profiles in the mouse brain.

He M, Liu Y, Wang X, Zhang MQ, Hannon GJ, Huang ZJ. Neuron. 2012

Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy.

Tan X, Lu ZJ, Gao G, Xu Q, Hu L, Fellmann C, Li MZ, Qu H, Lowe SW, Hannon GJ, Elledge SJ. Proc Natl Acad Sci U S A. 2012

Production of artificial piRNAs in flies and mice.

Muerdter F, Olovnikov I, Molaro A, Rozhkov NV, Czech B, Gordon A, Hannon GJ, Aravin AA. RNA. 2012

miR-34 miRNAs provide a barrier for somatic cell reprogramming.

Choi YJ, Lin CP, Ho JJ, He X, Okada N, Bu P, Zhong Y, Kim SY, Bennett MJ, Chen C, Ozturk A, Hicks GG, Hannon GJ, He L. Nat Cell Biol. 2011

Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates.

Molaro A, Hodges E, Fang F, Song Q, McCombie WR, Hannon GJ, Smith AD. Cell. 2011

Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment.

Hodges E, Molaro A, Dos Santos CO, Thekkat P, Song Q, Uren PJ, Park J, Butler J, Rafii S, McCombie WR, Smith AD, Hannon GJ. Mol Cell. 2011

Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas.

Lee S, Paulson KG, Murchison EP, Afanasiev OK, Alkan C, Leonard JH, Byrd DR, Hannon GJ, Nghiem P. J Clin Virol. 2011

Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila.

Zamparini AL, Davis MY, Malone CD, Vieira E, Zavadil J, Sachidanandam R, Hannon GJ, Lehmann R. Development. 2011

piRNA production requires heterochromatin formation in Drosophila.

Rangan P, Malone CD, Navarro C, Newbold SP, Hayes PS, Sachidanandam R, Hannon GJ, Lehmann R. Curr Biol. 2011

Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.

Tanaka T, Hosokawa M, Vagin VV, Reuter M, Hayashi E, Mochizuki AL, Kitamura K, Yamanaka H, Kondoh G, Okawa K, Kuramochi-Miyagawa S, Nakano T, Sachidanandam R, Hannon GJ, Pillai RS, Nakatsuji N, Chuma S. Proc Natl Acad Sci U S A. 2011

Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis.

Erlich Y, Edvardson S, Hodges E, Zenvirt S, Thekkat P, Shaag A, Dor T, Hannon GJ, Elpeleg O. Genome Res. 2011

A genome-scale shRNA resource for transgenic RNAi in Drosophila.

Ni JQ, Zhou R, Czech B, Liu LP, Holderbaum L, Yang-Zhou D, Shim HS, Tao R, Handler D, Karpowicz P, Binari R, Booker M, Brennecke J, Perkins LA, Hannon GJ, Perrimon N. Nat Methods. 2011

A rapid and scalable system for studying gene function in mice using conditional RNA interference.

Premsrirut PK, Dow LE, Kim SY, Camiolo M, Malone CD, Miething C, Scuoppo C, Zuber J, Dickins RA, Kogan SC, Shroyer KR, Sordella R, Hannon GJ, Lowe SW. Cell. 2011

Mutations in the RNA granule component TDRD7 cause cataract and glaucoma.

Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R, Yue Y, Tsai AC, Nair KS, Cosma MI, Smith RS, Hodges E, Alfadhli SM, Al-Hajeri A, Shamseldin HE, Behbehani A, Hannon GJ, Bulyk ML, Drack AV, Anderson PJ, et al. Science. 2011

Silencing of microRNA families by seed-targeting tiny LNAs.

Obad S, dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C, Lindow M, Stenvang J, Straarup EM, Hansen HF, Koch T, Pappin D, Hannon GJ, Kauppinen S. Nat Genet. 2011

Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage.

Spierings DC, McGoldrick D, Hamilton-Easton AM, Neale G, Murchison EP, Hannon GJ, Green DR, Withoff S. Blood. 2011

Functional identification of optimized RNAi triggers using a massively parallel sensor assay.

Fellmann C, Zuber J, McJunkin K, Chang K, Malone CD, Dickins RA, Xu Q, Hengartner MO, Elledge SJ, Hannon GJ, Lowe SW. Mol Cell. 2011

Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection.

Albert FW, Hodges E, Jensen JD, Besnier F, Xuan Z, Rooks M, Bhattacharjee A, Brizuela L, Good JM, Green RE, Burbano HA, Plyusnina IZ, Trut L, Andersson L, Schöneberg T, Carlborg O, Hannon GJ, Pääbo S. Heredity (Edinb). 2011

Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence.

Berezikov E, Robine N, Samsonova A, Westholm JO, Naqvi A, Hung JH, Okamura K, Dai Q, Bortolamiol-Becet D, Martin R, Zhao Y, Zamore PD, Hannon GJ, Marra MA, Weng Z, Perrimon N, Lai EC. Genome Res. 2011

Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi.

Zuber J, McJunkin K, Fellmann C, Dow LE, Taylor MJ, Hannon GJ, Lowe SW. Nat Biotechnol. 2011

Small RNA sorting: matchmaking for Argonautes.

Czech B, Hannon GJ. Nat Rev Genet. 2011

Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila.

Haase AD, Fenoglio S, Muerdter F, Guzzardo PM, Czech B, Pappin DJ, Chen C, Gordon A, Hannon GJ. Genes Dev. 2010

Ancestral roles of small RNAs: an Ago-centric perspective.

Joshua-Tor L, Hannon GJ. Cold Spring Harb Perspect Biol. 2011

Canonical and alternate functions of the microRNA biogenesis machinery.

Chong MM, Zhang G, Cheloufi S, Neubert TA, Hannon GJ, Littman DR. Genes Dev. 2010

Enrichment of poly(A)+ mRNA using immobilized oligo(dT).

Rio DC, Ares M Jr, Hannon GJ, Nilsen TW. Cold Spring Harb Protoc. 2010

Guidelines for the use of RNA purification kits.

Rio DC, Ares M Jr, Hannon GJ, Nilsen TW. Cold Spring Harb Protoc. 2010

Targeted enrichment of specific regions in the human genome by array hybridization.

Igartua C, Turner EH, Ng SB, Hodges E, Hannon GJ, Bhattacharjee A, Rieder MJ, Nickerson DA, Shendure J. Curr Protoc Hum Genet. 2010

Small RNA-based silencing strategies for transposons in the process of invading Drosophila species.

Rozhkov NV, Aravin AA, Zelentsova ES, Schostak NG, Sachidanandam R, McCombie WR, Hannon GJ, Evgen’ev MB. RNA. 2010

Determining the yield and quality of purified RNA.

Rio DC, Ares M Jr, Hannon GJ, Nilsen TW. Cold Spring Harb Protoc. 2010

Nondenaturing agarose gel electrophoresis of RNA.

Rio DC, Ares M Jr, Hannon GJ, Nilsen TW. Cold Spring Harb Protoc. 2010

Polyacrylamide gel electrophoresis of RNA.

Rio DC, Ares M Jr, Hannon GJ, Nilsen TW. Cold Spring Harb Protoc. 2010

Removal of DNA from RNA.

Rio DC, Ares M Jr, Hannon GJ, Nilsen TW. Cold Spring Harb Protoc. 2010

Preparation of cytoplasmic and nuclear RNA from tissue culture cells.

Rio DC, Ares M Jr, Hannon GJ, Nilsen TW. Cold Spring Harb Protoc. 2010

Ethanol precipitation of RNA and the use of carriers.

Rio DC, Ares M Jr, Hannon GJ, Nilsen TW. Cold Spring Harb Protoc. 2010

Purification of RNA using TRIzol (TRI reagent).

Rio DC, Ares M Jr, Hannon GJ, Nilsen TW. Cold Spring Harb Protoc. 2010

Purification of RNA by SDS solubilization and phenol extraction.

Rio DC, Ares M Jr, Hannon GJ, Nilsen TW. Cold Spring Harb Protoc. 2010

The RNA interference system differently responds to the same mobile element in distant Drosophila species.

Rozhkov NV, Aravin AA, Sachidanandam R, Hannon GJ, Sokolova ON, Zelentsova ES, Shostak NG, Evgen’ev MB. Dokl Biochem Biophys. 2010

Molecular evolution of piRNA and transposon control pathways in Drosophila.

Malone CD, Hannon GJ. Cold Spring Harb Symp Quant Biol. 2009

Targeted investigation of the Neandertal genome by array-based sequence capture.

Burbano HA, Hodges E, Green RE, Briggs AW, Krause J, Meyer M, Good JM, Maricic T, Johnson PL, Xuan Z, Rooks M, Bhattacharjee A, Brizuela L, Albert FW, de la Rasilla M, Fortea J, Rosas A, Lachmann M, Hannon GJ, Pääbo S. Science. 2010

A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity.

Cifuentes D, Xue H, Taylor DW, Patnode H, Mishima Y, Cheloufi S, Ma E, Mane S, Hannon GJ, Lawson ND, Wolfe SA, Giraldez AJ. Science. 2010

Cheloufi S, Dos Santos CO, Chong MM, Hannon GJ. Nature. 2010

Deep sequencing of target linkage assay-identified regions in familial breast cancer: methods, analysis pipeline and troubleshooting.

Rosa-Rosa JM, Gracia-Aznárez FJ, Hodges E, Pita G, Rooks M, Xuan Z, Bhattacharjee A, Brizuela L, Silva JM, Hannon GJ, Benitez J. PLoS One. 2010

Ancient animal microRNAs and the evolution of tissue identity.

Christodoulou F, Raible F, Tomer R, Simakov O, Trachana K, Klaus S, Snyman H, Hannon GJ, Bork P, Arendt D. Nature. 2010

Compressed Genotyping.

Erlich Y, Gordon A, Brand M, Hannon GJ, Mitra PP. IEEE Trans Inf Theory. 2010

The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer.

Murchison EP, Tovar C, Hsu A, Bender HS, Kheradpour P, Rebbeck CA, Obendorf D, Conlan C, Bahlo M, Blizzard CA, Pyecroft S, Kreiss A, Kellis M, Stark A, Harkins TT, Marshall Graves JA, Woods GM, Hannon GJ, Papenfuss AT. Science. 2010

Evolutionary flux of canonical microRNAs and mirtrons in Drosophila.

Berezikov E, Liu N, Flynt AS, Hodges E, Rooks M, Hannon GJ, Lai EC. Nat Genet. 2010

Joubert syndrome 2 (JBTS2) in Ashkenazi Jews is associated with a TMEM216 mutation.

Edvardson S, Shaag A, Zenvirt S, Erlich Y, Hannon GJ, Shanske AL, Gomori JM, Ekstein J, Elpeleg O. Am J Hum Genet. 2010

Cytoplasmic compartmentalization of the fetal piRNA pathway in mice.

Aravin AA, van der Heijden GW, Castañeda J, Vagin VV, Hannon GJ, Bortvin A. PLoS Genet. 2009

miR-19 is a key oncogenic component of mir-17-92.

Olive V, Bennett MJ, Walker JC, Ma C, Jiang I, Cordon-Cardo C, Li QJ, Lowe SW, Hannon GJ, He L. Genes Dev. 2009

Arginine methylation as a molecular signature of the Piwi small RNA pathway.

Vagin VV, Hannon GJ, Aravin AA. Cell Cycle. 2009

Hierarchical rules for Argonaute loading in Drosophila.

Czech B, Zhou R, Erlich Y, Brennecke J, Binari R, Villalta C, Gordon A, Perrimon N, Hannon GJ. Mol Cell. 2009

Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.

Bric A, Miething C, Bialucha CU, Scuoppo C, Zender L, Krasnitz A, Xuan Z, Zuber J, Wigler M, Hicks J, McCombie RW, Hemann MT, Hannon GJ, Powers S, Lowe SW. Cancer Cell. 2009

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

Fabian MR, Mathonnet G, Sundermeier T, Mathys H, Zipprich JT, Svitkin YV, Rivas F, Jinek M, Wohlschlegel J, Doudna JA, Chen CY, Shyu AB, Yates JR 3rd, Hannon GJ, Filipowicz W, Duchaine TF, Sonenberg N. Mol Cell. 2009

The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response.

Castellano L, Giamas G, Jacob J, Coombes RC, Lucchesi W, Thiruchelvam P, Barton G, Jiao LR, Wait R, Waxman J, Hannon GJ, Stebbing J. Proc Natl Acad Sci U S A. 2009

Cell contact-dependent acquisition of cellular and viral nonautonomously encoded small RNAs.

Rechavi O, Erlich Y, Amram H, Flomenblit L, Karginov FV, Goldstein I, Hannon GJ, Kloog Y. Genes Dev. 2009

Sequence, biogenesis, and function of diverse small RNA classes bound to the Piwi family proteins of Tetrahymena thermophila.

Couvillion MT, Lee SR, Hogstad B, Malone CD, Tonkin LA, Sachidanandam R, Hannon GJ, Collins K. Genes Dev. 2009

Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform.

Zhou R, Czech B, Brennecke J, Sachidanandam R, Wohlschlegel JA, Perrimon N, Hannon GJ. RNA. 2009

Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.

Vagin VV, Wohlschlegel J, Qu J, Jonsson Z, Huang X, Chuma S, Girard A, Sachidanandam R, Hannon GJ, Aravin AA. Genes Dev. 2009

High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing.

Hodges E, Smith AD, Kendall J, Xuan Z, Ravi K, Rooks M, Zhang MQ, Ye K, Bhattacharjee A, Brizuela L, McCombie WR, Wigler M, Hannon GJ, Hicks JB. Genome Res. 2009

Cyfip1 is a putative invasion suppressor in epithelial cancers.

Silva JM, Ezhkova E, Silva J, Heart S, Castillo M, Campos Y, Castro V, Bonilla F, Cordon-Cardo C, Muthuswamy SK, Powers S, Fuchs E, Hannon GJ. Cell. 2009

Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing.

Hodges E, Rooks M, Xuan Z, Bhattacharjee A, Benjamin Gordon D, Brizuela L, Richard McCombie W, Hannon GJ. Nat Protoc. 2009

DNA Sudoku–harnessing high-throughput sequencing for multiplexed specimen analysis.

Erlich Y, Chang K, Gordon A, Ronen R, Navon O, Rooks M, Hannon GJ. Genome Res. 2009

Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary.

Malone CD, Brennecke J, Dus M, Stark A, McCombie WR, Sachidanandam R, Hannon GJ. Cell. 2009

Small RNA silencing pathways in germ and stem cells.

Aravin AA, Hannon GJ. Cold Spring Harb Symp Quant Biol. 2008

Small RNAs as guardians of the genome.

Malone CD, Hannon GJ. Cell. 2009

Design of 240,000 orthogonal 25mer DNA barcode probes.

Xu Q, Schlabach MR, Hannon GJ, Elledge SJ. Proc Natl Acad Sci U S A. 2009

An epigenetic role for maternally inherited piRNAs in transposon silencing.

Brennecke J, Malone CD, Aravin AA, Sachidanandam R, Stark A, Hannon GJ. Science. 2008

Comparative analysis of argonaute-dependent small RNA pathways in Drosophila.

Zhou R, Hotta I, Denli AM, Hong P, Perrimon N, Hannon GJ. Mol Cell. 2008

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer.

Zender L, Xue W, Zuber J, Semighini CP, Krasnitz A, Ma B, Zender P, Kubicka S, Luk JM, Schirmacher P, McCombie WR, Wigler M, Hicks J, Hannon GJ, Powers S, Lowe SW. Cell. 2008

A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice.

Aravin AA, Sachidanandam R, Bourc’his D, Schaefer C, Pezic D, Toth KF, Bestor T, Hannon GJ. Mol Cell. 2008

Alta-Cyclic: a self-optimizing base caller for next-generation sequencing.

Erlich Y, Mitra PP, delaBastide M, McCombie WR, Hannon GJ. Nat Methods. 2008

Topoisomerase levels determine chemotherapy response in vitro and in vivo.

Burgess DJ, Doles J, Zender L, Xue W, Ma B, McCombie WR, Hannon GJ, Lowe SW, Hemann MT. Proc Natl Acad Sci U S A. 2008

[The role of piRNAs in mouse spermatogenesis.].

Girard A, Hannon GJ. J Soc Biol. 2007

Genome analysis of the platypus reveals unique signatures of evolution.

Warren WC, Hillier LW, Marshall Graves JA, Birney E, Ponting CP, Grützner F, Belov K, Miller W, Clarke L, Chinwalla AT, Yang SP, Heger A, Locke DP, Miethke P, Waters PD, Veyrunes F, Fulton L, Fulton B, Graves T, Wallis J, Puente XS, López-Otín C, et al. Nature. 2008

An endogenous small interfering RNA pathway in Drosophila.

Czech B, Malone CD, Zhou R, Stark A, Schlingeheyde C, Dus M, Perrimon N, Kellis M, Wohlschlegel JA, Sachidanandam R, Hannon GJ, Brennecke J. Nature. 2008

Conservation of small RNA pathways in platypus.

Murchison EP, Kheradpour P, Sachidanandam R, Smith C, Hodges E, Xuan Z, Kellis M, Grützner F, Stark A, Hannon GJ. Genome Res. 2008

Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc.

Tworkowski KA, Chakraborty AA, Samuelson AV, Seger YR, Narita M, Hannon GJ, Lowe SW, Tansey WP. Proc Natl Acad Sci U S A. 2008

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes.

Tam OH, Aravin AA, Stein P, Girard A, Murchison EP, Cheloufi S, Hodges E, Anger M, Sachidanandam R, Schultz RM, Hannon GJ. Nature. 2008

Astrin regulates Aurora-A localization.

Du J, Jablonski S, Yen TJ, Hannon GJ. Biochem Biophys Res Commun. 2008

Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5′ terminal nucleotide.

Mi S, Cai T, Hu Y, Chen Y, Hodges E, Ni F, Wu L, Li S, Zhou H, Long C, Chen S, Hannon GJ, Qi Y. Cell. 2008

Conserved themes in small-RNA-mediated transposon control.

Girard A, Hannon GJ. Trends Cell Biol. 2008

Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure.

Chen JF, Murchison EP, Tang R, Callis TE, Tatsuguchi M, Deng Z, Rojas M, Hammond SM, Schneider MD, Selzman CH, Meissner G, Patterson C, Hannon GJ, Wang DZ. Proc Natl Acad Sci U S A. 2008

Cancer proliferation gene discovery through functional genomics.

Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, Hannon GJ, Elledge SJ. Science. 2008

Profiling essential genes in human mammary cells by multiplex RNAi screening.

Silva JM, Marran K, Parker JS, Silva J, Golding M, Schlabach MR, Elledge SJ, Hannon GJ, Chang K. Science. 2008

Analysis of large-scale sequencing of small RNAs.

Olson AJ, Brennecke J, Aravin AA, Hannon GJ, Sachidanandam R. Pac Symp Biocomput. 2008

Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci.

Tyler DM, Okamura K, Chung WJ, Hagen JW, Berezikov E, Hannon GJ, Lai EC. Genes Dev. 2008

Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor.

Haiser HJ, Karginov FV, Hannon GJ, Elliot MA. Nucleic Acids Res. 2008

A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells.

Ibarra I, Erlich Y, Muthuswamy SK, Sachidanandam R, Hannon GJ. Genes Dev. 2007

He X, He L, Hannon GJ. Cancer Res. 2007

A biochemical approach to identifying microRNA targets.

Karginov FV, Conaco C, Xuan Z, Schmidt BH, Parker JS, Mandel G, Hannon GJ. Proc Natl Acad Sci U S A. 2007

Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures.

Stark A, Lin MF, Kheradpour P, Pedersen JS, Parts L, Carlson JW, Crosby MA, Rasmussen MD, Roy S, Deoras AN, Ruby JG, Brennecke J; Harvard FlyBase curators; Berkeley Drosophila Genome Project, Hodges E, Hinrichs AS, Caspi A, Paten B, Park SW, Han MV, Maeder ML, Polansky BJ, et al. Nature. 2007

Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes.

Stark A, Kheradpour P, Parts L, Brennecke J, Hodges E, Hannon GJ, Kellis M. Genome Res. 2007

Genome-wide in situ exon capture for selective resequencing.

Hodges E, Xuan Z, Balija V, Kramer M, Molla MN, Smith SW, Middle CM, Rodesch MJ, Albert TJ, Hannon GJ, McCombie WR. Nat Genet. 2007

microRNAs join the p53 network–another piece in the tumour-suppression puzzle.

He L, He X, Lowe SW, Hannon GJ. Nat Rev Cancer. 2007

Tissue-specific and reversible RNA interference in transgenic mice.

Dickins RA, McJunkin K, Hernando E, Premsrirut PK, Krizhanovsky V, Burgess DJ, Kim SY, Cordon-Cardo C, Zender L, Hannon GJ, Lowe SW. Nat Genet. 2007

A microRNA component of the p53 tumour suppressor network.

He L, He X, Lim LP, de Stanchina E, Xuan Z, Liang Y, Xue W, Zender L, Magnus J, Ridzon D, Jackson AL, Linsley PS, Chen C, Lowe SW, Cleary MA, Hannon GJ. Nature. 2007

A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii.

Zhao T, Li G, Mi S, Li S, Hannon GJ, Wang XJ, Qi Y. Genes Dev. 2007

Developmentally regulated piRNA clusters implicate MILI in transposon control.

Aravin AA, Sachidanandam R, Girard A, Fejes-Toth K, Hannon GJ. Science. 2007

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.

Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER 3rd, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ. Nature. 2007

A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish.

Houwing S, Kamminga LM, Berezikov E, Cronembold D, Girard A, van den Elst H, Filippov DV, Blaser H, Raz E, Moens CB, Plasterk RH, Hannon GJ, Draper BW, Ketting RF. Cell. 2007

A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW, Elledge SJ. Nat Cell Biol. 2007

MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.

Carmell MA, Girard A, van de Kant HJ, Bourc’his D, Bestor TH, de Rooij DG, Hannon GJ. Dev Cell. 2007

The expanding universe of noncoding RNAs.

Hannon GJ, Rivas FV, Murchison EP, Steitz JA. Cold Spring Harb Symp Quant Biol. 2006

Critical roles for Dicer in the female germline.

Murchison EP, Stein P, Xuan Z, Pan H, Zhang MQ, Schultz RM, Hannon GJ. Genes Dev. 2007

Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.

Brennecke J, Aravin AA, Stark A, Dus M, Kellis M, Sachidanandam R, Hannon GJ. Cell. 2007

Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma.

Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L. Genes Dev. 2007

Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation.

Qi Y, He X, Wang XJ, Kohany O, Jurka J, Hannon GJ. Nature. 2006

Lessons from Nature: microRNA-based shRNA libraries.

Chang K, Elledge SJ, Hannon GJ. Nat Methods. 2006

Generation and analysis of genetically defined liver carcinomas derived from bipotential liver progenitors.

Zender L, Xue W, Cordón-Cardo C, Hannon GJ, Lucito R, Powers S, Flemming P, Spector MS, Lowe SW. Cold Spring Harb Symp Quant Biol. 2005

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach.

Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, Fan ST, Luk JM, Wigler M, Hannon GJ, Mu D, Lucito R, Powers S, Lowe SW. Cell. 2006

A germline-specific class of small RNAs binds mammalian Piwi proteins.

Girard A, Sachidanandam R, Hannon GJ, Carmell MA. Nature. 2006

The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles.

Andl T, Murchison EP, Liu F, Zhang Y, Yunta-Gonzalez M, Tobias JW, Andl CD, Seykora JT, Hannon GJ, Millar SE. Curr Biol. 2006

Suppression of prion protein in livestock by RNA interference.

Golding MC, Long CR, Carmell MA, Hannon GJ, Westhusin ME. Proc Natl Acad Sci U S A. 2006

Control of translation and mRNA degradation by miRNAs and siRNAs.

Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R. Genes Dev. 2006

A role for the P-body component GW182 in microRNA function.

Liu J, Rivas FV, Wohlschlegel J, Yates JR 3rd, Parker R, Hannon GJ. Nat Cell Biol. 2005

Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts.

Mason DX, Keppler D, Zhang J, Jackson TJ, Seger YR, Matsui S, Abreo F, Cowell JK, Hannon GJ, Lowe SW, Lin AW. Carcinogenesis. 2006

An open letter to cancer researchers.

Elledge SJ, Hannon GJ. Science. 2005

Retraction: RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription.

Schramke V, Sheedy DM, Denli AM, Bonila C, Ekwall K, Hannon GJ, Allshire RC. Nature. 2005

Second-generation shRNA libraries covering the mouse and human genomes.

Silva JM, Li MZ, Chang K, Ge W, Golding MC, Rickles RJ, Siolas D, Hu G, Paddison PJ, Schlabach MR, Sheth N, Bradshaw J, Burchard J, Kulkarni A, Cavet G, Sachidanandam R, McCombie WR, Cleary MA, Elledge SJ, Hannon GJ. Nat Genet. 2005

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors.

Dickins RA, Hemann MT, Zilfou JT, Simpson DR, Ibarra I, Hannon GJ, Lowe SW. Nat Genet. 2005

Cloning of short hairpin RNAs for gene knockdown in mammalian cells.

Paddison PJ, Cleary M, Silva JM, Chang K, Sheth N, Sachidanandam R, Hannon GJ. Nat Methods. 2004

A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells.

Stegmeier F, Hu G, Rickles RJ, Hannon GJ, Elledge SJ. Proc Natl Acad Sci U S A. 2005

Characterization of Dicer-deficient murine embryonic stem cells.

Murchison EP, Partridge JF, Tam OH, Cheloufi S, Hannon GJ. Proc Natl Acad Sci U S A. 2005

RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription.

Schramke V, Sheedy DM, Denli AM, Bonila C, Ekwall K, Hannon GJ, Allshire RC. Nature. 2005

A genetic screen for candidate tumor suppressors identifies REST.

Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ. Cell. 2005

A microRNA polycistron as a potential human oncogene.

He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ, Hammond SM. Nature. 2005

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies.

Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R. Nat Cell Biol. 2005

Purified Argonaute2 and an siRNA form recombinant human RISC.

Rivas FV, Tolia NH, Song JJ, Aragon JP, Liu J, Hannon GJ, Joshua-Tor L. Nat Struct Mol Biol. 2005

Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis.

Cleary MA, Kilian K, Wang Y, Bradshaw J, Cavet G, Ge W, Kulkarni A, Paddison PJ, Chang K, Sheth N, Leproust E, Coffey EM, Burchard J, McCombie WR, Linsley P, Hannon GJ. Nat Methods. 2004

Synthetic shRNAs as potent RNAi triggers.

Siolas D, Lerner C, Burchard J, Ge W, Linsley PS, Paddison PJ, Hannon GJ, Cleary MA. Nat Biotechnol. 2005

Processing of primary microRNAs by the Microprocessor complex.

Denli AM, Tops BB, Plasterk RH, Ketting RF, Hannon GJ. Nature. 2004

Argonaute2 is the catalytic engine of mammalian RNAi.

Liu J, Carmell MA, Rivas FV, Marsden CG, Thomson JM, Song JJ, Hammond SM, Joshua-Tor L, Hannon GJ. Science. 2004

Crystal structure of Argonaute and its implications for RISC slicer activity.

Song JJ, Smith SK, Hannon GJ, Joshua-Tor L. Science. 2004

MicroRNAs: small RNAs with a big role in gene regulation.

He L, Hannon GJ. Nat Rev Genet. 2004

Suppression of tumorigenesis by the p53 target PUMA.

Hemann MT, Zilfou JT, Zhao Z, Burgess DJ, Hannon GJ, Lowe SW. Proc Natl Acad Sci U S A. 2004

miRNAs on the move: miRNA biogenesis and the RNAi machinery.

Murchison EP, Hannon GJ. Curr Opin Cell Biol. 2004

Short hairpin activated gene silencing in mammalian cells.

Paddison PJ, Caudy AA, Sachidanandam R, Hannon GJ. Methods Mol Biol. 2004

RNA interference microarrays: high-throughput loss-of-function genetics in mammalian cells.

Silva JM, Mizuno H, Brady A, Lucito R, Hannon GJ. Proc Natl Acad Sci U S A. 2004

RNAi and expression of retrotransposons MuERV-L and IAP in preimplantation mouse embryos.

Svoboda P, Stein P, Anger M, Bernstein E, Hannon GJ, Schultz RM. Dev Biol. 2004

A resource for large-scale RNA-interference-based screens in mammals.

Paddison PJ, Silva JM, Conklin DS, Schlabach M, Li M, Aruleba S, Balija V, O’Shaughnessy A, Gnoj L, Scobie K, Chang K, Westbrook T, Cleary M, Sachidanandam R, McCombie WR, Elledge SJ, Hannon GJ. Nature. 2004

RNase III enzymes and the initiation of gene silencing.

Carmell MA, Hannon GJ. Nat Struct Mol Biol. 2004

RNA interference by short hairpin RNAs expressed in vertebrate cells.

Hannon GJ, Conklin DS. Methods Mol Biol. 2004

Inducible, reversible, and stable RNA interference in mammalian cells.

Gupta S, Schoer RA, Egan JE, Hannon GJ, Mittal V. Proc Natl Acad Sci U S A. 2004

Free energy lights the path toward more effective RNAi.

Silva JM, Sachidanandam R, Hannon GJ. Nat Genet. 2003

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes.

Song JJ, Liu J, Tolia NH, Schneiderman J, Smith SK, Martienssen RA, Hannon GJ, Joshua-Tor L. Nat Struct Biol. 2003

Dicer is essential for mouse development.

Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, Mills AA, Elledge SJ, Anderson KV, Hannon GJ. Nat Genet. 2003

A micrococcal nuclease homologue in RNAi effector complexes.

Caudy AA, Ketting RF, Hammond SM, Denli AM, Bathoorn AM, Tops BB, Silva JM, Myers MM, Hannon GJ, Plasterk RH. Nature. 2003

siRNAs and shRNAs: skeleton keys to the human genome.

Paddison PJ, Hannon GJ. Curr Opin Mol Ther. 2003

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.

Narita M, Nũnez S, Heard E, Narita M, Lin AW, Hearn SA, Spector DL, Hannon GJ, Lowe SW. Cell. 2003

RNAi: an ever-growing puzzle.

Denli AM, Hannon GJ. Trends Biochem Sci. 2003

A survey of canine expressed sequence tags and a display of their annotations through a flexible web-based interface.

Palmer LE, O’Shaughnessy AL, Preston RR, Santos L, Balija VS, Nascimento LU, Zutavern TL, Henthorn PS, Hannon GJ, McCombie WR. J Hered. 2003

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo.

Hemann MT, Fridman JS, Zilfou JT, Hernando E, Paddison PJ, Cordon-Cardo C, Hannon GJ, Lowe SW. Nat Genet. 2003

Germline transmission of RNAi in mice.

Carmell MA, Zhang L, Conklin DS, Hannon GJ, Rosenquist TA. Nat Struct Biol. 2003

Transformation of normal human cells in the absence of telomerase activation.

Seger YR, García-Cao M, Piccinin S, Cunsolo CL, Doglioni C, Blasco MA, Hannon GJ, Maestro R. Cancer Cell. 2002

RNA interference: a promising approach to antiviral therapy?

Silva JM, Hammond SM, Hannon GJ. Trends Mol Med. 2002

Fragile X-related protein and VIG associate with the RNA interference machinery.

Caudy AA, Myers M, Hannon GJ, Hammond SM. Genes Dev. 2002

RNA interference: the new somatic cell genetics?

Paddison PJ, Hannon GJ. Cancer Cell. 2002

RNA interference.

Hannon GJ. Nature. 2002

RNA interference in adult mice.

McCaffrey AP, Meuse L, Pham TT, Conklin DS, Hannon GJ, Kay MA. Nature. 2002

Oncogenic ras and p53 cooperate to induce cellular senescence.

Ferbeyre G, de Stanchina E, Lin AW, Querido E, McCurrach ME, Hannon GJ, Lowe SW. Mol Cell Biol. 2002

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells.

Paddison PJ, Caudy AA, Bernstein E, Hannon GJ, Conklin DS. Genes Dev. 2002

Stable suppression of gene expression by RNAi in mammalian cells.

Paddison PJ, Caudy AA, Hannon GJ. Proc Natl Acad Sci U S A. 2002

The rest is silence.

Bernstein E, Denli AM, Hannon GJ. RNA. 2001

Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor.

Stolarov J, Chang K, Reiner A, Rodgers L, Hannon GJ, Wigler MH, Mittal V. Proc Natl Acad Sci U S A. 2001

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans.

Ketting RF, Fischer SE, Bernstein E, Sijen T, Hannon GJ, Plasterk RH. Genes Dev. 2001

Argonaute2, a link between genetic and biochemical analyses of RNAi.

Hammond SM, Boettcher S, Caudy AA, Kobayashi R, Hannon GJ. Science. 2001

Post-transcriptional gene silencing by double-stranded RNA.

Hammond SM, Caudy AA, Hannon GJ. Nat Rev Genet. 2001

Role for a bidentate ribonuclease in the initiation step of RNA interference.

Bernstein E, Caudy AA, Hammond SM, Hannon GJ. Nature. 2001

Loss-of-function genetics in mammalian cells: the p53 tumor suppressor model.

Carnero A, Hudson JD, Hannon GJ, Beach DH. Nucleic Acids Res. 2000

Risky immortalization by telomerase.

Wang J, Hannon GJ, Beach DH. Nature. 2000

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells.

Hammond SM, Bernstein E, Beach D, Hannon GJ. Nature. 2000

A proinflammatory cytokine inhibits p53 tumor suppressor activity.

Hudson JD, Shoaibi MA, Maestro R, Carnero A, Hannon GJ, Beach DH. J Exp Med. 1999

Twist is a potential oncogene that inhibits apoptosis.

Maestro R, Dei Tos AP, Hamamori Y, Krasnokutsky S, Sartorelli V, Kedes L, Doglioni C, Beach DH, Hannon GJ. Genes Dev. 1999

MaRX: an approach to genetics in mammalian cells.

Hannon GJ, Sun P, Carnero A, Xie LY, Maestro R, Conklin DS, Beach D. Science. 1999

p53-independent role of MDM2 in TGF-beta1 resistance.

Sun P, Dong P, Dai K, Hannon GJ, Beach D. Science. 1998

Myc activates telomerase.

Wang J, Xie LY, Allan S, Beach D, Hannon GJ. Genes Dev. 1998

The INK4 family of CDK inhibitors.

Carnero A, Hannon GJ. Curr Top Microbiol Immunol. 1998

Plant cells contain a novel member of the retinoblastoma family of growth regulatory proteins.

Xie Q, Sanz-Burgos AP, Hannon GJ, Gutiérrez C. EMBO J. 1996

Growth suppression of esophageal cancer cells by p16INK4 and p15INK4B in vitro.

Zhou X, Suzuki H, Lei J, Cole K, Yin J, Suzuki V, Abraham JM, Shimada Y, Imamura M, Chan T, Hannon GJ, Meltzer SJ. Cancer J Sci Am. 1996

Deletion of the p16 and p15 genes in human bladder tumors.

Orlow I, Lacombe L, Hannon GJ, Serrano M, Pellicer I, Dalbagni G, Reuter VE, Zhang ZF, Beach D, Cordon-Cardo C. J Natl Cancer Inst. 1995

Radiation-induced cell cycle arrest compromised by p21 deficiency.

Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T, Hannon GJ. Nature. 1995

Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers.

Suzuki H, Zhou X, Yin J, Lei J, Jiang HY, Suzuki Y, Chan T, Hannon GJ, Mergner WJ, Abraham JM, et al. Hum Mol Genet. 1995

Cloning and characterization of murine p16INK4a and p15INK4b genes.

Quelle DE, Ashmun RA, Hannon GJ, Rehberger PA, Trono D, Richter KH, Walker C, Beach D, Sherr CJ, Serrano M. Oncogene. 1995

Mutations associated with familial melanoma impair p16INK4 function.

Ranade K, Hussussian CJ, Sikorski RS, Varmus HE, Goldstein AM, Tucker MA, Serrano M, Hannon GJ, Beach D, Dracopoli NC. Nat Genet. 1995

Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer.

Okamoto A, Hussain SP, Hagiwara K, Spillare EA, Rusin MR, Demetrick DJ, Serrano M, Hannon GJ, Shiseki M, Zariwala M, et al. Cancer Res. 1995

Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD.

Halevy O, Novitch BG, Spicer DB, Skapek SX, Rhee J, Hannon GJ, Beach D, Lassar AB. Science. 1995

Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3).

Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH. Cytogenet Cell Genet. 1995

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair.

Li R, Waga S, Hannon GJ, Beach D, Stillman B. Nature. 1994

Construction of an improved host strain for two hybrid screening.

Feilotter HE, Hannon GJ, Ruddell CJ, Beach D. Nucleic Acids Res. 1994

KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases.

Hannon GJ, Casso D, Beach D. Proc Natl Acad Sci U S A. 1994

p21 is a component of active cell cycle kinases.

Zhang H, Hannon GJ, Casso D, Beach D. Cold Spring Harb Symp Quant Biol. 1994

p21 is a universal inhibitor of cyclin kinases.

Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D. Nature. 1993

The nematode spliced leader RNA participates in trans-splicing as an Sm snRNP.

Maroney PA, Hannon GJ, Denker JA, Nilsen TW. EMBO J. 1990

Trans splicing of nematode pre-messenger RNA in vitro.

Hannon GJ, Maroney PA, Denker JA, Nilsen TW. Cell. 1990

Transcription and cap trimethylation of a nematode spliced leader RNA in a cell-free system.

Maroney PA, Hannon GJ, Nilsen TW. Proc Natl Acad Sci U S A. 1990

Accurate processing of human pre-rRNA in vitro.

Hannon GJ, Maroney PA, Branch A, Benenfield BJ, Robertson HD, Nilsen TW. Mol Cell Biol. 1989

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