Cancer Research

 

Heterogeneity

A barcoding strategy to study breast cancer heterogeneity. Adapted from Wagenblast et al. (2015) Nature

The Hannon lab seeks to address critical problems in cancer biology, focusing mainly on breast and pancreatic cancers. We study several areas of disease initiation and progression, including the characterization of early lesions in breast cancer and the behaviour of disease during periods of remission. We also have a particular interest in tumour heterogeneity and in mining the intrinsic phenotypic differences between subpopulations of cells in tumor models to identify critical pathways of disease progression (Wagenblast et al., 2015). In all of these contexts we apply a variety of cutting edge genomic and genetic tools to identify new targets for cancer therapy.

To learn more about some of our cancer projects, click here.